The infamous school for 'young ladies', St Trinian's, is once again facing dire financial crisis. While unorthodox headmistress Camilla Fritton struggles to deal with the new Education Minister Geoffrey Thwaites' tireless advances and his unyielding objective of transforming her chaotic establishment into a 'respectable' ladies' college, the responsibility for saving St Trinian's from its creditors falls to the anarchic pupils. The fearless girls gather together a motley crew of teachers, associates, and the rest of the school‘s ungovernable and uninhibited pranksters, who, using their wit, sass, determination and ingenuity, attempt to pull off the heist of the century and save the school from impending bankruptcy.
